Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 CCR2 💬 3件: Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Chemokine signaling pathway Cenicriviroc mesylate 💬 Cenicriviroc 1件: 94 💬
2 CCR2 💬 3件: Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Chemokine signaling pathway Cenicriviroc 💬 Cenicriviroc 1件: 94 💬
3 CCR5 💬 11件: Viral life cycle - HIV-1, Virion - Human immunodeficiency virus, Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Chemokine signaling pathway, Endocytosis, Toxoplasmosis, Human cytomegalovirus infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, Viral carcinogenesis Cenicriviroc mesylate 💬 Cenicriviroc 1件: 94 💬
4 CCR5 💬 11件: Viral life cycle - HIV-1, Virion - Human immunodeficiency virus, Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Chemokine signaling pathway, Endocytosis, Toxoplasmosis, Human cytomegalovirus infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, Viral carcinogenesis Cenicriviroc 💬 Cenicriviroc 1件: 94 💬
5 CD2 💬 2件: Cell adhesion molecules, Hematopoietic cell lineage Siplizumab 💬 Siplizumab 2件: 94, 95 💬
6 DHODH 💬 1件: Pyrimidine metabolism Vidofludimus 💬 Vidofludimus 5件: 13, 46, 94, 96, 97 💬
7 DHODH 💬 1件: Pyrimidine metabolism Vidofludimus calcium 💬 Vidofludimus 5件: 13, 46, 94, 96, 97 💬
8 EGFR 💬 47件: Virion - Hepatitis viruses, MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Phospholipase D signaling pathway, Endocytosis, PI3K-Akt signaling pathway, Focal adhesion, Adherens junction, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, GnRH signaling pathway, Estrogen signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Cushing syndrome, Epithelial cell signaling in Helicobacter pylori infection, Shigellosis, Hepatitis C, Human cytomegalovirus infection, Human papillomavirus infection, Coronavirus disease - COVID-19, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Chemical carcinogenesis - receptor activation, Chemical carcinogenesis - reactive oxygen species, Colorectal cancer, Pancreatic cancer, Endometrial cancer, Glioma, Prostate cancer, Melanoma, Bladder cancer, Non-small cell lung cancer, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Central carbon metabolism in cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer Erlotinib 💬 Erlotinib 2件: 94, 160 💬
9 EGFR 💬 47件: Virion - Hepatitis viruses, MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Phospholipase D signaling pathway, Endocytosis, PI3K-Akt signaling pathway, Focal adhesion, Adherens junction, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, GnRH signaling pathway, Estrogen signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Cushing syndrome, Epithelial cell signaling in Helicobacter pylori infection, Shigellosis, Hepatitis C, Human cytomegalovirus infection, Human papillomavirus infection, Coronavirus disease - COVID-19, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Chemical carcinogenesis - receptor activation, Chemical carcinogenesis - reactive oxygen species, Colorectal cancer, Pancreatic cancer, Endometrial cancer, Glioma, Prostate cancer, Melanoma, Bladder cancer, Non-small cell lung cancer, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Central carbon metabolism in cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer Erlotinib hydrochloride 💬 Erlotinib 2件: 94, 160 💬
10 FGF19 💬 10件: MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Pathways in cancer, Melanoma, Breast cancer, Gastric cancer Aldafermin 💬 Aldafermin 1件: 94 💬
11 HMGCR 💬 3件: Terpenoid backbone biosynthesis, AMPK signaling pathway, Bile secretion Simvastatin 💬 Simvastatin 21件: 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310 💬
12 HMGCR 💬 3件: Terpenoid backbone biosynthesis, AMPK signaling pathway, Bile secretion Rosuvastatin 💬 Rosuvastatin 13件: 6, 18, 46, 49, 51, 56, 65, 79, 94, 96, 97, 271, 299 💬
13 HMGCR 💬 3件: Terpenoid backbone biosynthesis, AMPK signaling pathway, Bile secretion Rosuvastatin calcium 💬 Rosuvastatin 13件: 6, 18, 46, 49, 51, 56, 65, 79, 94, 96, 97, 271, 299 💬
14 IMPDH 💬 2件: Purine metabolism, Drug metabolism - other enzymes Mizoribine 💬 Mizoribine 8件: 46, 49, 51, 53, 66, 94, 222, 224 💬
15 IMPDH 💬 2件: Purine metabolism, Drug metabolism - other enzymes Mizoribine 💬 Mizoribine 8件: 46, 49, 51, 53, 66, 94, 222, 224 💬
16 ITGA4 💬 15件: PI3K-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, Cell adhesion molecules, Hematopoietic cell lineage, Leukocyte transendothelial migration, Intestinal immune network for IgA production, Regulation of actin cytoskeleton, Cytoskeleton in muscle cells, Yersinia infection, Leishmaniasis, Human papillomavirus infection, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Vedolizumab 💬 Vedolizumab 3件: 94, 96, 97 💬
17 ITGA5 💬 19件: Virion - Herpesvirus, Phagosome, PI3K-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, Hematopoietic cell lineage, Regulation of actin cytoskeleton, Cytoskeleton in muscle cells, Bacterial invasion of epithelial cells, Shigellosis, Pertussis, Yersinia infection, Human papillomavirus infection, Herpes simplex virus 1 infection, Proteoglycans in cancer, MicroRNAs in cancer, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Bexotegrast 💬 Bexotegrast 1件: 94 💬
18 ITGB1 💬 27件: Virion - Rotavirus, Rap1 signaling pathway, Phagosome, PI3K-Akt signaling pathway, Axon guidance, Focal adhesion, ECM-receptor interaction, Cell adhesion molecules, Tight junction, Platelet activation, Leukocyte transendothelial migration, Regulation of actin cytoskeleton, Cytoskeleton in muscle cells, Bacterial invasion of epithelial cells, Pathogenic Escherichia coli infection, Shigellosis, Pertussis, Yersinia infection, Leishmaniasis, Toxoplasmosis, Human papillomavirus infection, Pathways in cancer, Proteoglycans in cancer, Small cell lung cancer, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Bexotegrast 💬 Bexotegrast 1件: 94 💬
19 ITGB6 💬 9件: PI3K-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, Regulation of actin cytoskeleton, Cytoskeleton in muscle cells, Human papillomavirus infection, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Bexotegrast 💬 Bexotegrast 1件: 94 💬
20 ITGB7 💬 12件: PI3K-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, Cell adhesion molecules, Intestinal immune network for IgA production, Regulation of actin cytoskeleton, Cytoskeleton in muscle cells, Human papillomavirus infection, Transcriptional misregulation in cancer, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Vedolizumab 💬 Vedolizumab 3件: 94, 96, 97 💬
21 MS4A1 💬 1件: Hematopoietic cell lineage Rituximab 💬 Rituximab 52件: 11, 13, 14, 19, 26, 34, 35, 36, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 53, 55, 56, 60, 61, 62, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 162, 172, 220, 222, 229, 256, 271, 274, 283, 284, 285, 288, 296, 300, 331 💬
22 NR1C1 💬 10件: PPAR signaling pathway, cAMP signaling pathway, Adipocytokine signaling pathway, Glucagon signaling pathway, Insulin resistance, Non-alcoholic fatty liver disease, Alcoholic liver disease, Hepatitis C, Chemical carcinogenesis - receptor activation, Diabetic cardiomyopathy Elafibranor 💬 Elafibranor 2件: 93, 94 💬
23 NR1C1 💬 10件: PPAR signaling pathway, cAMP signaling pathway, Adipocytokine signaling pathway, Glucagon signaling pathway, Insulin resistance, Non-alcoholic fatty liver disease, Alcoholic liver disease, Hepatitis C, Chemical carcinogenesis - receptor activation, Diabetic cardiomyopathy Fenofibrate 💬 Fenofibrate 6件: 8, 79, 93, 94, 97, 265 💬
24 NR1C1 💬 10件: PPAR signaling pathway, cAMP signaling pathway, Adipocytokine signaling pathway, Glucagon signaling pathway, Insulin resistance, Non-alcoholic fatty liver disease, Alcoholic liver disease, Hepatitis C, Chemical carcinogenesis - receptor activation, Diabetic cardiomyopathy Bezafibrate 💬 Bezafibrate 8件: 20, 93, 94, 160, 296, 316, 324, 344 💬
25 NR1C3 💬 12件: PPAR signaling pathway, Efferocytosis, AMPK signaling pathway, Longevity regulating pathway, Osteoclast differentiation, Thermogenesis, Non-alcoholic fatty liver disease, Huntington disease, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer, Lipid and atherosclerosis Seladelpar 💬 Seladelpar 2件: 93, 94 💬
26 NR1C3 💬 12件: PPAR signaling pathway, Efferocytosis, AMPK signaling pathway, Longevity regulating pathway, Osteoclast differentiation, Thermogenesis, Non-alcoholic fatty liver disease, Huntington disease, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer, Lipid and atherosclerosis Seladelpar lysine 💬 Seladelpar 2件: 93, 94 💬
27 NR1H4 💬 1件: Bile secretion Ursodiol 💬 Ursodeoxycholic acid 14件: 6, 8, 20, 46, 67, 84, 93, 94, 95, 96, 97, 234, 296, 299 💬
28 NR3C1 💬 1件: Neuroactive ligand-receptor interaction Budesonide 💬 Budesonide 9件: 66, 93, 94, 95, 96, 97, 98, 228, 299 💬
29 PML 💬 7件: Ubiquitin mediated proteolysis, Endocytosis, Influenza A, Herpes simplex virus 1 infection, Pathways in cancer, Transcriptional misregulation in cancer, Acute myeloid leukemia Tretinoin 💬 Tretinoin 6件: 2, 62, 63, 75, 94, 231 💬
30 RARA 💬 5件: Th17 cell differentiation, Estrogen signaling pathway, Pathways in cancer, Transcriptional misregulation in cancer, Acute myeloid leukemia Tretinoin 💬 Tretinoin 6件: 2, 62, 63, 75, 94, 231 💬
31 RARB 💬 4件: Pathways in cancer, Small cell lung cancer, Non-small cell lung cancer, Gastric cancer Tretinoin 💬 Tretinoin 6件: 2, 62, 63, 75, 94, 231 💬
32 RRM1 💬 4件: Purine metabolism, Pyrimidine metabolism, Glutathione metabolism, Drug metabolism - other enzymes Cladribine 💬 Cladribine 3件: 11, 13, 94 💬
33 thyA 💬 3件: Pyrimidine metabolism, One carbon pool by folate, Folate transport and metabolism Capecitabine 💬 Capecitabine 1件: 94 💬
34 TNF 💬 66件: MAPK signaling pathway, Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, NF-kappa B signaling pathway, Sphingolipid signaling pathway, mTOR signaling pathway, Apoptosis, Necroptosis, TGF-beta signaling pathway, Osteoclast differentiation, Antigen processing and presentation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, C-type lectin receptor signaling pathway, Hematopoietic cell lineage, Natural killer cell mediated cytotoxicity, IL-17 signaling pathway, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, TNF signaling pathway, Adipocytokine signaling pathway, Type II diabetes mellitus, Insulin resistance, Non-alcoholic fatty liver disease, AGE-RAGE signaling pathway in diabetic complications, Alcoholic liver disease, Type I diabetes mellitus, Alzheimer disease, Amyotrophic lateral sclerosis, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Shigellosis, Salmonella infection, Pertussis, Legionellosis, Yersinia infection, Leishmaniasis, Chagas disease, African trypanosomiasis, Malaria, Toxoplasmosis, Amoebiasis, Tuberculosis, Hepatitis C, Hepatitis B, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Human immunodeficiency virus 1 infection, Coronavirus disease - COVID-19, Proteoglycans in cancer, Asthma, Inflammatory bowel disease, Systemic lupus erythematosus, Rheumatoid arthritis, Allograft rejection, Graft-versus-host disease, Hypertrophic cardiomyopathy, Dilated cardiomyopathy, Lipid and atherosclerosis, Fluid shear stress and atherosclerosis Thalidomide 💬 Thalidomide 21件: 2, 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 117, 227, 271, 280, 298, 300, 331 💬