Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 BTK 💬 7件: NF-kappa B signaling pathway, Osteoclast differentiation, Platelet activation, B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Epstein-Barr virus infection, Primary immunodeficiency Zanubrutinib 💬 Zanubrutinib 7件: 13, 48, 61, 63, 222, 300, 331 💬
2 C5 💬 11件: Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Neutrophil extracellular trap formation, Regulation of actin cytoskeleton, Alcoholic liver disease, Prion disease, Pertussis, Staphylococcus aureus infection, Herpes simplex virus 1 infection, Coronavirus disease, Systemic lupus erythematosus Crovalimab 💬 Crovalimab 3件: 48, 62, 109 💬
3 CD38 💬 6件: Nicotinate and nicotinamide metabolism, Calcium signaling pathway, Hematopoietic cell lineage, Oxytocin signaling pathway, Salivary secretion, Pancreatic secretion Daratumumab 💬 Daratumumab 13件: 13, 16, 28, 39, 46, 48, 49, 60, 63, 222, 223, 288, 331 💬
4 F10 💬 1件: Complement and coagulation cascades Rivaroxaban 💬 Rivaroxaban 10件: 46, 48, 49, 56, 58, 75, 91, 210, 222, 271 💬
5 F10 💬 1件: Complement and coagulation cascades Apixaban 💬 Apixaban 6件: 48, 96, 97, 222, 223, 279 💬
6 HMGCR 💬 3件: Terpenoid backbone biosynthesis, AMPK signaling pathway, Bile secretion Fluvastatin sodium 💬 Fluvastatin 4件: 48, 79, 218, 222 💬
7 HMGCR 💬 3件: Terpenoid backbone biosynthesis, AMPK signaling pathway, Bile secretion Fluvastatin 💬 Fluvastatin 4件: 48, 79, 218, 222 💬
8 IFNAR1 💬 18件: Cytokine-cytokine receptor interaction, PI3K-Akt signaling pathway, Necroptosis, Osteoclast differentiation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, JAK-STAT signaling pathway, Natural killer cell mediated cytotoxicity, Hepatitis C, Hepatitis B, Measles, Influenza A, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Coronavirus disease, Pathways in cancer Anifrolumab 💬 Anifrolumab 6件: 46, 48, 49, 50, 51, 53 💬
9 IFNAR2 💬 17件: Cytokine-cytokine receptor interaction, PI3K-Akt signaling pathway, Necroptosis, Osteoclast differentiation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, JAK-STAT signaling pathway, Natural killer cell mediated cytotoxicity, Hepatitis C, Measles, Influenza A, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Coronavirus disease, Pathways in cancer Anifrolumab 💬 Anifrolumab 6件: 46, 48, 49, 50, 51, 53 💬
10 ITGAL 💬 14件: Rap1 signaling pathway, Cell adhesion molecule (CAM) interaction, IgSF CAM signaling, Integrin signaling, Neutrophil extracellular trap formation, Natural killer cell mediated cytotoxicity, Leukocyte transendothelial migration, Regulation of actin cytoskeleton, Malaria, Staphylococcus aureus infection, Human T-cell leukemia virus 1 infection, Epstein-Barr virus infection, Rheumatoid arthritis, Viral myocarditis Efalizumab 💬 Efalizumab 10件: 11, 13, 37, 46, 48, 53, 61, 95, 96, 221 💬
11 MS4A1 💬 1件: Hematopoietic cell lineage Rituximab 💬 Rituximab 54件: 11, 13, 14, 19, 26, 34, 35, 36, 40, 41, 42, 43, 44, 45, 46, 48, 49, 50, 51, 52, 53, 55, 56, 60, 61, 62, 63, 64, 65, 66, 83, 84, 85, 86, 88, 93, 94, 96, 97, 162, 172, 222, 223, 229, 256, 271, 274, 283, 284, 285, 288, 296, 300, 331 💬
12 MTOR 💬 52件: ErbB signaling pathway, HIF-1 signaling pathway, Phospholipase D signaling pathway, Autophagy - other, Autophagy - animal, Lysosome biogenesis, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Integrated stress response (ISR) signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Cellular senescence, Apelin signaling pathway, Integrin signaling, Neutrophil extracellular trap formation, JAK-STAT signaling pathway, Th17 cell differentiation, Thermogenesis, Insulin signaling pathway, Thyroid hormone signaling pathway, Adipocytokine signaling pathway, Type II diabetes mellitus, Insulin resistance, Growth hormone synthesis, secretion and action, Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Pathways of neurodegeneration - multiple diseases, Shigellosis, Human cytomegalovirus infection, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Chemical carcinogenesis - receptor activation, Colorectal cancer, Pancreatic cancer, Glioma, Prostate cancer, Acute myeloid leukemia, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Central carbon metabolism in cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Diabetic cardiomyopathy Sirolimus 💬 Sirolimus 46件: 6, 13, 15, 17, 19, 21, 34, 35, 36, 46, 48, 49, 51, 54, 57, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 97, 98, 111, 127, 137, 157, 158, 192, 222, 223, 227, 277, 278, 279, 280, 281, 283, 285, 300, 331 💬
13 NQO1 💬 5件: Ubiquinone and other terpenoid-quinone biosynthesis, Pathways in cancer, Chemical carcinogenesis - reactive oxygen species, Hepatocellular carcinoma, Fluid shear stress and atherosclerosis Warfarin sodium 💬 Warfarin 15件: 6, 8, 13, 19, 46, 48, 49, 66, 85, 86, 88, 91, 96, 97, 222 💬
14 NQO1 💬 5件: Ubiquinone and other terpenoid-quinone biosynthesis, Pathways in cancer, Chemical carcinogenesis - reactive oxygen species, Hepatocellular carcinoma, Fluid shear stress and atherosclerosis Warfarin 💬 Warfarin 15件: 6, 8, 13, 19, 46, 48, 49, 66, 85, 86, 88, 91, 96, 97, 222 💬
15 NQO1 💬 5件: Ubiquinone and other terpenoid-quinone biosynthesis, Pathways in cancer, Chemical carcinogenesis - reactive oxygen species, Hepatocellular carcinoma, Fluid shear stress and atherosclerosis Warfarin potassium 💬 Warfarin 15件: 6, 8, 13, 19, 46, 48, 49, 66, 85, 86, 88, 91, 96, 97, 222 💬
16 NR3C1 💬 1件: Neuroactive ligand-receptor interaction Prednisone 💬 Prednisone 58件: 2, 11, 13, 14, 18, 19, 26, 28, 35, 40, 41, 42, 43, 44, 45, 46, 48, 49, 50, 51, 53, 60, 61, 63, 64, 65, 66, 79, 81, 84, 85, 86, 90, 93, 95, 96, 97, 113, 127, 145, 162, 164, 205, 222, 223, 224, 228, 251, 269, 283, 284, 285, 288, 299, 300, 303, 307, 331 💬
17 P2RY12 💬 3件: Neuroactive ligand signaling, Efferocytosis, Platelet activation Ticlopidine hydrochloride 💬 Ticlopidine 1件: 48 💬
18 P2RY12 💬 3件: Neuroactive ligand signaling, Efferocytosis, Platelet activation Ticlopidine 💬 Ticlopidine 1件: 48 💬
19 PDE3A 💬 5件: Purine metabolism, cGMP-PKG signaling pathway, cAMP signaling pathway, Renin secretion, Morphine addiction Cilostazol 💬 Cilostazol 7件: 6, 13, 46, 48, 51, 70, 124 💬
20 PDE3B 💬 10件: Purine metabolism, cGMP-PKG signaling pathway, cAMP signaling pathway, Apelin signaling pathway, Insulin signaling pathway, Progesterone-mediated oocyte maturation, Glucagon signaling pathway, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction Cilostazol 💬 Cilostazol 7件: 6, 13, 46, 48, 51, 70, 124 💬
21 SERPINC1 💬 1件: Complement and coagulation cascades Danaparoid sodium 💬 Danaparoid 1件: 48 💬
22 SERPINC1 💬 1件: Complement and coagulation cascades Heparin calcium 💬 Heparin 15件: 47, 48, 60, 65, 70, 79, 84, 107, 224, 226, 280, 299, 316, 317, 344 💬
23 SERPINC1 💬 1件: Complement and coagulation cascades Heparin sodium 💬 Heparin 15件: 47, 48, 60, 65, 70, 79, 84, 107, 224, 226, 280, 299, 316, 317, 344 💬
24 SERPINC1 💬 1件: Complement and coagulation cascades Enoxaparin sodium 💬 Enoxaparin 6件: 46, 48, 71, 222, 223, 327 💬
25 SERPINC1 💬 1件: Complement and coagulation cascades Adomiparin 💬 Enoxaparin 6件: 46, 48, 71, 222, 223, 327 💬
26 TBXA2R 💬 3件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Platelet activation Cilostazol 💬 Cilostazol 7件: 6, 13, 46, 48, 51, 70, 124 💬
27 TNF 💬 66件: MAPK signaling pathway, Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, NF-kappa B signaling pathway, Sphingolipid signaling pathway, mTOR signaling pathway, Apoptosis, Necroptosis, TGF-beta signaling pathway, Osteoclast differentiation, Antigen processing and presentation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, C-type lectin receptor signaling pathway, Hematopoietic cell lineage, Natural killer cell mediated cytotoxicity, IL-17 signaling pathway, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, TNF signaling pathway, Adipocytokine signaling pathway, Type II diabetes mellitus, Insulin resistance, Non-alcoholic fatty liver disease, AGE-RAGE signaling pathway in diabetic complications, Alcoholic liver disease, Type I diabetes mellitus, Alzheimer disease, Amyotrophic lateral sclerosis, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Shigellosis, Salmonella infection, Pertussis, Legionellosis, Yersinia infection, Leishmaniasis, Chagas disease, African trypanosomiasis, Malaria, Toxoplasmosis, Amoebiasis, Tuberculosis, Hepatitis C, Hepatitis B, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Human immunodeficiency virus 1 infection, Coronavirus disease, Proteoglycans in cancer, Asthma, Inflammatory bowel disease, Systemic lupus erythematosus, Rheumatoid arthritis, Allograft rejection, Graft-versus-host disease, Hypertrophic cardiomyopathy, Dilated cardiomyopathy, Lipid and atherosclerosis, Fluid shear stress and atherosclerosis Certolizumab pegol 💬 Certolizumab pegol 10件: 37, 40, 46, 48, 49, 96, 97, 107, 226, 271 💬
28 TNFSF13B 💬 4件: Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Intestinal immune network for IgA production, Rheumatoid arthritis Belimumab 💬 Belimumab 17件: 11, 13, 43, 44, 46, 48, 49, 50, 51, 53, 63, 66, 95, 222, 223, 296, 300 💬
29 VKORC1 💬 1件: Ubiquinone and other terpenoid-quinone biosynthesis Warfarin 💬 Warfarin 15件: 6, 8, 13, 19, 46, 48, 49, 66, 85, 86, 88, 91, 96, 97, 222 💬
30 VKORC1 💬 1件: Ubiquinone and other terpenoid-quinone biosynthesis Warfarin potassium 💬 Warfarin 15件: 6, 8, 13, 19, 46, 48, 49, 66, 85, 86, 88, 91, 96, 97, 222 💬
31 VKORC1 💬 1件: Ubiquinone and other terpenoid-quinone biosynthesis Warfarin sodium 💬 Warfarin 15件: 6, 8, 13, 19, 46, 48, 49, 66, 85, 86, 88, 91, 96, 97, 222 💬